福井大学、坂野先生Gとの共同開発がE-lifeに掲載されました！

マウスの親和性を司る神経回路の同定、その機能分子が幼少期にオキシトシンを介して働くことで、生涯にわたる安全基地としての社会シグナルが記銘されることがわかりました。"The Olfactory Critical Period is Determined by Activity-Dependent Sema7A/PlxnC1 Signaling within Glomeruli"

Acceptance Summary:

This manuscript investigates a role for Sema7A/PlxnC1 in an olfactory critical period. The authors observed that mice who encounter odors as neonates (before ~P7) display altered behavioral and neuronal responses to those odors as adults. Neonatal-experienced odors are investigated more vigorously, and mildly reduce stress, perhaps akin to familiar nest odors. Disruption of Plxn1 alters neuronal circuitry and eliminates the behavioral effects of neonatal odor exposure.